MeSH Browser

MeSH Heading: Clonal Hematopoiesis
Tree Number(s): G04.152.825.207; G04.375.500; G05.158.500; G09.188.343.207
Unique ID: D000082182
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000082182
Scope Note: Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).
Entry Term(s): ARCH Age-related Clonal Hematopoiesis; Age-related Clonal Hematopoiesis; CCUS Clonal Cytopenia of Undetermined Significance; CHIP Clonal Hematopoiesis of Indeterminate Potential; Clonal Cytopenia of Undetermined Significance; Clonal Hematopoiesis of Indeterminate Potential; ICUS Idiopathic Cytopenias of Undetermined Significance; Idiopathic Cytopenias of Undetermined Significance
Previous Indexing: Hematopoiesis (1989-2020)
Public MeSH Note: 2021
History Note: 2021
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/05/27

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Clonal Hematopoiesis MeSH Descriptor Data 2022