Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).
Entry Term(s)
ARCH Age-related Clonal Hematopoiesis
Age-related Clonal Hematopoiesis
CCUS Clonal Cytopenia of Undetermined Significance
CHIP Clonal Hematopoiesis of Indeterminate Potential
Clonal Cytopenia of Undetermined Significance
Clonal Hematopoiesis of Indeterminate Potential
ICUS Idiopathic Cytopenias of Undetermined Significance
Idiopathic Cytopenias of Undetermined Significance
Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).
