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Senescence-Associated Secretory Phenotype MeSH Descriptor Data 2025


MeSH Heading
Senescence-Associated Secretory Phenotype
Tree Number(s)
G04.043.445
G07.345.124.130.445
Unique ID
D000089262
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000089262
Scope Note
A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.
Entry Term(s)
Senescent Cell SASP
Public MeSH Note
2022; see CELLULAR SENESCENCE 2018-2021
History Note
2022; use CELLULAR SENESCENCE 2018-2021
Date Established
2022/01/01
Date of Entry
2021/07/09
Revision Date
2021/07/07
Senescence-Associated Secretory Phenotype Preferred
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