MeSH Browser

MeSH Heading: Degrons
Tree Number(s): G02.111.570.820.709.275.625
Unique ID: D000097791
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000097791
Scope Note: Minimal elements within a protein that are sufficient for recognition and degradation by a proteolytic apparatus. Inherent degrons are comprised of short linear amino acid sequences and secondary protein structural features that increase the affinity to E3 LIGASE; and are involved in regulating the specificity and timing of PROTEIN DEGRADATION. Acquired degrons are mostly transient and conferred by post-translational modifications of specific amino acids within proteins. (From Mol Cell. 2016 Sep 15;63(6):1055-65)
Entry Term(s): C-Degrons; D-Box Motif; Destruction Box; Destruction Box Motif; Destruction Boxes; N-Degrons; PEST Motif; PEST Sequence
Public MeSH Note: 2024
History Note: 2024
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/05/26

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M000764448
Terms: Destruction Box Motif Preferred Term
Term UI T001137211
Date05/05/2023
LexicalTag NON
ThesaurusID NLM (2024); Destruction Boxes
Term UI T001136424
Date04/18/2023
LexicalTag NON
ThesaurusID NLM (2024); Destruction Box
Term UI T001136423
Date04/18/2023
LexicalTag NON
ThesaurusID NLM (2024); D-Box Motif
Term UI T001137212
Date05/05/2023
LexicalTag NON
ThesaurusID NLM (2024)

Degrons MeSH Descriptor Data 2024