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Dosage Compensation, Genetic MeSH Descriptor Data 2023


MeSH Heading
Dosage Compensation, Genetic
Tree Number(s)
G05.308.203.249
Unique ID
D004303
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004303
Annotation
do not confuse with GENE DOSAGE
Scope Note
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Entry Term(s)
Dosage Compensation (Genetics)
Gene Dosage Compensation
Hypertranscription, X-Chromosome
X-Chromosome Hypertranscription
Previous Indexing
Sex Chromosomes (1968-1981)
X Chromosome (1978-1981)
Public MeSH Note
2006; see DOSAGE COMPENSATION (GENETICS) 1982-2005
History Note
2006 (1982)
Date Established
1982/01/01
Date of Entry
1981/02/23
Revision Date
2016/06/17
Dosage Compensation, Genetic Preferred
X-Chromosome Hypertranscription Narrower
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