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Immunoglobulin Class Switching MeSH Descriptor Data 2023


MeSH Heading
Immunoglobulin Class Switching
Tree Number(s)
G05.344.401.501.450
G12.500.274.501.450
Unique ID
D017578
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017578
Scope Note
Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.
Entry Version
IG CLASS SWITCHING
Entry Term(s)
Class Switching
Ig Class Switching
Isotype Switching
Previous Indexing
Immunoglobulin Isotypes/biosynthesis (1988-1993)
Immunoglobulins, Heavy-Chain/genetics (1980-1993)
Public MeSH Note
94
History Note
94
Date Established
1994/01/01
Date of Entry
1993/06/17
Revision Date
2019/07/05
Immunoglobulin Class Switching Preferred
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