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Trans-Splicing MeSH Descriptor Data 2022


MeSH Heading
Trans-Splicing
Tree Number(s)
G02.111.760.700.750
G03.839.700.750
G05.308.700.700.750
Unique ID
D020040
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020040
Annotation
note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING
Scope Note
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Entry Term(s)
RNA Trans-Splicing
Trans RNA Splicing
Trans Splicing
Previous Indexing
RNA Splicing (1982-1998)
See Also
RNA, Spliced Leader
Public MeSH Note
99
History Note
99
Date Established
1999/01/01
Date of Entry
1998/06/11
Revision Date
2016/07/01
Trans-Splicing Preferred
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