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Surface Plasmon Resonance MeSH Descriptor Data 2022

MeSH Heading
Surface Plasmon Resonance
Tree Number(s)
Unique ID
RDF Unique Identifier
do not confuse with plasmon, extrachromosomal genetic material
Scope Note
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
NLM Classification #
QT 36.4
Previous Indexing
Biosensing Techniques (1991-1998)
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
Surface Plasmon Resonance Preferred
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