MeSH Browser

MeSH Heading: Antineoplastic Agents, Alkylating
Tree Number(s): D27.505.519.124.035; D27.505.954.248.150; D27.888.569.035.035
Unique ID: D018906
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018906
Scope Note: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Entry Version: ANTINEOPL AGENTS ALKYLATING
Entry Term(s): Alkylating Agents, Antineoplastic; Alkylating Antineoplastic Agents; Alkylating Antineoplastic Drugs; Alkylating Antineoplastics; Alkylating Drugs, Antineoplastic; Antineoplastic Alkylating Agents; Antineoplastic Drugs, Alkylating; Antineoplastics, Alkylating
Previous Indexing: Alkylating Agents (1966-1995); Antineoplastic Agents (1966-1995)
Public MeSH Note: 96
History Note: 96
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2014/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Molecular Mechanisms of Pharmacological Action [D27.505.519]
    - Alkylating Agents [D27.505.519.124]
      - Antineoplastic Agents, Alkylating [D27.505.519.124.035]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Therapeutic Uses [D27.505.954]
    - Antineoplastic Agents [D27.505.954.248]

Chemical Actions and Uses [D27]
- Toxic Actions [D27.888]
  - Noxae [D27.888.569]
    - Alkylating Agents [D27.888.569.035]
      - Antineoplastic Agents, Alkylating [D27.888.569.035.035]

Antineoplastic Agents, Alkylating Preferred

Concept UI: M0028268
Scope Note: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Terms: Antineoplastic Agents, Alkylating Preferred Term
Term UI T056347
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1996); Alkylating Antineoplastic Agents
Term UI T056344
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Alkylating Antineoplastic Drugs
Term UI T056350
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Alkylating Antineoplastics
Term UI T056348
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Alkylating Agents, Antineoplastic
Term UI T056346
Date08/26/1994
LexicalTag NON
ThesaurusID NLM (1996); Antineoplastic Alkylating Agents
Term UI T056345
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Antineoplastic Drugs, Alkylating
Term UI T056352
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Antineoplastics, Alkylating
Term UI T056349
Date01/22/1995
LexicalTag NON
ThesaurusID NLM (1996); Alkylating Drugs, Antineoplastic
Term UI T056351
Date03/21/1995
LexicalTag NON
ThesaurusID NLM (1996)

Antineoplastic Agents, Alkylating MeSH Descriptor Data 2024