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Antineoplastic Agents, Alkylating MeSH Descriptor Data 2022


MeSH Heading
Antineoplastic Agents, Alkylating
Tree Number(s)
D27.505.519.124.035
D27.505.954.248.150
D27.888.569.035.035
Unique ID
D018906
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018906
Scope Note
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Entry Version
ANTINEOPL AGENTS ALKYLATING
Entry Term(s)
Alkylating Agents, Antineoplastic
Alkylating Antineoplastic Agents
Alkylating Antineoplastic Drugs
Alkylating Antineoplastics
Alkylating Drugs, Antineoplastic
Antineoplastic Alkylating Agents
Antineoplastic Drugs, Alkylating
Antineoplastics, Alkylating
Registry Number
0
Previous Indexing
Alkylating Agents (1966-1995)
Antineoplastic Agents (1966-1995)
Public MeSH Note
96
History Note
96
Date Established
1996/01/01
Date of Entry
1995/05/26
Revision Date
2014/06/25
Antineoplastic Agents, Alkylating Preferred
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