MeSH Browser

MeSH Heading: Calgranulin A
Tree Number(s): D12.776.157.125.750.500.100; D12.776.631.658.750.500; D23.050.301.562.100
Unique ID: D040501
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D040501
Scope Note: A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
Entry Term(s): 60B8-B Antigen; CABP-P8; Cystic Fibrosis Antigen; Leukocyte L1 Protein Light Chain; MRP-8 Protein; MRP8 Protein; Macrophage-Related Protein-8; Myeloid Calcium-Binding Protein P8; S100 A8 Protein; S100A8 Protein
Registry Number: 0
Previous Indexing: Antigens, Differentiation (1989-2002); Calcium-Binding Proteins (1989-2002)
Public MeSH Note: 2003; CALGRANULIN A was indexed under CALCIUM-BINDING BINDING PROTEINS 1989-2002; MRP-8 PROTEIN (now CALGRANULIN A) was indexed under ANTIGENS, DIFFERENTIATION & CALCIUM-BINDING PROTEINS 1989-2002
History Note: 2003; use CALGRANULIN A (NM) 1998-2002;
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2023/06/09

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Calcium-Binding Proteins [D12.776.157.125]
      - S100 Proteins [D12.776.157.125.750]
        
        Leukocyte L1 Antigen Complex [D12.776.157.125.750.500]
        
        Calgranulin A [D12.776.157.125.750.500.100]
        
        Calgranulin B [D12.776.157.125.750.500.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - S100 Proteins [D12.776.631.658]
      - Leukocyte L1 Antigen Complex [D12.776.631.658.750]
        
        Calgranulin A [D12.776.631.658.750.500]
        
        Calgranulin B [D12.776.631.658.750.750]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Leukocyte L1 Antigen Complex [D23.050.301.562]
      - Calgranulin A [D23.050.301.562.100]
      - Calgranulin B [D23.050.301.562.200]

Calgranulin A Preferred

Concept UI: M0169795
Registry Number: 0
Scope Note: A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
Terms: Calgranulin A Preferred Term
Term UI T199800
LexicalTag NON
ThesaurusID NLM (2003); S100A8 Protein
Term UI T440644
Date03/24/2001
LexicalTag ACX
ThesaurusID NLM (2003); Leukocyte L1 Protein Light Chain
Term UI T491021
Date04/25/2002
LexicalTag NON
ThesaurusID NLM (2003); Cystic Fibrosis Antigen
Term UI T152498
LexicalTag NON
ThesaurusID NLM (2003); MRP-8 Protein
Term UI T209360
LexicalTag NON
ThesaurusID NLM (2003); CABP-P8
Term UI T209354
LexicalTag ACR
ThesaurusID NLM (2003); MRP8 Protein
Term UI T209355
LexicalTag NON
ThesaurusID NLM (2003); Macrophage-Related Protein-8
Term UI T209358
LexicalTag NON
ThesaurusID NLM (2003); Myeloid Calcium-Binding Protein P8
Term UI T209359
LexicalTag ACX
ThesaurusID NLM (2003); S100 A8 Protein
Term UI T436453
Date02/16/2001
LexicalTag ACX
ThesaurusID NLM (2003); 60B8-B Antigen
Term UI T209353
LexicalTag NON
ThesaurusID NLM (2003)

Calgranulin A MeSH Descriptor Data 2024