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Substrate Cycling MeSH Descriptor Data 2022


MeSH Heading
Substrate Cycling
Tree Number(s)
G02.111.833
G03.295.835
Unique ID
D015219
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D015219
Annotation
restricted to enzyme activity; almost never IM; coord NIM with specific enzyme (IM)
Scope Note
A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
Entry Term(s)
Futile Cycles
Futile Cycling
Futile Substrate Cycles
Futile Substrate Cycling
Previous Indexing
Energy Metabolism (1975-1988)
specific substance/metabolism (1975-1988)
Public MeSH Note
89
History Note
89
Date Established
1989/01/01
Date of Entry
1988/05/11
Revision Date
2016/07/01
Substrate Cycling Preferred
Futile Cycles Narrower
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