MeSH Browser

MeSH Heading: Down-Regulation
Tree Number(s): G02.111.240; G05.308.200; G07.690.773.937
Unique ID: D015536
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015536
Scope Note: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Entry Term(s): Down-Regulation (Physiology); Downregulation; Receptor Down-Regulation
See Also: Feedback, Physiological; Up-Regulation
Public MeSH Note: 2002; see Down-Regulation (Physiology) 1990-2001
History Note: 2002 (1990)
Date Established: 1990/01/01
Date of Entry: 1989/05/26
Revision Date: 2016/06/17

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Down-Regulation MeSH Descriptor Data 2025