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Nucleic Acid Denaturation MeSH Descriptor Data 2022


MeSH Heading
Nucleic Acid Denaturation
Tree Number(s)
E05.393.640
G02.111.603
G05.627
Unique ID
D009691
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D009691
Annotation
IM general only; coord NIM with DNA or RNA or specific (IM)
Scope Note
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Entry Term(s)
DNA Denaturation
DNA Melting
RNA Denaturation
See Also
RNA Stability
Public MeSH Note
70
History Note
70(67)
Date Established
1970/01/01
Date of Entry
1999/01/01
Revision Date
2016/06/17
Nucleic Acid Denaturation Preferred
RNA Denaturation Narrower
DNA Denaturation Narrower
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