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DNA Damage MeSH Descriptor Data 2022


MeSH Heading
DNA Damage
Tree Number(s)
G05.200
Unique ID
D004249
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004249
Annotation
do not use /‌drug eff & /‌rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
Scope Note
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Entry Term(s)
DNA Injury
Genotoxic Stress
Injury, DNA
Stress, Genotoxic
NLM Classification #
QU 510
Previous Indexing
DNA (1966-1986)
DNA Repair (1971-1986)
DNA Replication (1968-1986)
See Also
Mutation
Pyrimidine Dimers
Public MeSH Note
87
History Note
87
Date Established
1987/01/01
Date of Entry
1986/06/19
Revision Date
2016/06/17
DNA Damage Preferred
Genotoxic Stress Narrower
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