NLM Logo

Gene Amplification MeSH Descriptor Data 2022


MeSH Heading
Gene Amplification
Tree Number(s)
G05.308.250
G05.365.590.310
G05.558.315
Unique ID
D005784
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D005784
Annotation
for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics
Scope Note
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
NLM Classification #
QU 475
Previous Indexing
Genes (1966-1967)
Genes, Structural (1968-1979)
Nucleic Acid Hybridization (1971-1979)
Plasmids (1975-1979)
See Also
Gene Dosage
Public MeSH Note
80
History Note
80
Entry Combination
methods:Nucleic Acid Amplification Techniques
Date Established
1980/01/01
Date of Entry
1979/04/17
Revision Date
2016/06/17
Gene Amplification Preferred
page delivered in 0.153s