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Mutagenesis, Insertional MeSH Descriptor Data 2022


MeSH Heading
Mutagenesis, Insertional
Tree Number(s)
E05.393.420.601.550
G05.365.590.575
G05.558.550
Unique ID
D016254
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016254
Scope Note
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Entry Term(s)
Gene Insertion
Insertion Mutation
Insertional Activation
Insertional Mutagenesis
Linker-Insertion Mutagenesis
Mutagenesis, Cassette
Sequence Insertion
Viral Insertional Mutagenesis
NLM Classification #
QU 55.95
Previous Indexing
DNA Insertion Elements (1983-1990)
Mutation (1982-1990)
See Also
DNA Transposable Elements
Public MeSH Note
91
History Note
91
Date Established
1991/01/01
Date of Entry
1990/05/29
Revision Date
2018/06/29
Mutagenesis, Insertional Preferred
Sequence Insertion Related
Viral Insertional Mutagenesis Narrower
Linker-Insertion Mutagenesis Narrower
Gene Insertion Related
Insertion Mutation Related
Insertional Activation Broader
Mutagenesis, Cassette Narrower
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