MeSH Browser

MeSH Heading: Codon, Nonsense
Tree Number(s): D13.444.735.544.355.250.235; G05.360.335.355.250.235; G05.365.590.195
Unique ID: D018389
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018389
Annotation: for amber or ochre suppressor mutations use SUPPRESSION, GENETIC
Scope Note: An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
Entry Term(s): Amber Nonsense Codon; Amber Nonsense Mutation; Codon, Termination, Premature; Codon, Unassigned; Mutation, Nonsense; Nonsense Codon; Nonsense Codon, Amber; Nonsense Mutation; Ochre Nonsense Codon; Ochre Nonsense Mutation; Opal Nonsense Codon; Opal Nonsense Mutation; Premature Stop Codon; Premature Termination Codon; Unassigned Codon
Previous Indexing: Codon (1975-1994); Genetic Code (1966-1974)
Public MeSH Note: 95
History Note: 95
Date Established: 1995/01/01
Date of Entry: 1994/06/03
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0027616
Scope Note: An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
Terms: Codon, Nonsense Preferred Term
Term UI T054831
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1995); Codon, Termination, Premature
Term UI T414290
Date05/15/2000
LexicalTag NON
ThesaurusID NLM (2001); Premature Stop Codon
Term UI T414291
Date05/15/2000
LexicalTag NON
ThesaurusID NLM (2001); Premature Termination Codon
Term UI T414292
Date05/15/2000
LexicalTag NON
ThesaurusID NLM (2001); Nonsense Codon
Term UI T054830
Date01/06/1994
LexicalTag NON
ThesaurusID NLM (1995)

Codon, Nonsense MeSH Descriptor Data 2024