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Loss of Function Mutation
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Loss of Function Mutation
Tree Number(s)
G05.365.590.538
Unique ID
D000073658
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073658
Scope Note
A mutation that causes a decrease in or elimination of a gene product's activity.
Entry Term(s)
Leaky Mutation
Null Mutation
Previous Indexing
Mutation (1989-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/30
Allowable Qualifiers
drug effects (DE)
genetics (GE)
immunology (IM)
physiology (PH)
radiation effects (RE)
Genetic Phenomena [G05]
Genetic Variation [G05.365]
Mutation [G05.365.590]
Allelic Imbalance [G05.365.590.029]
Base Pair Mismatch [G05.365.590.060]
Chromosome Aberrations [G05.365.590.175]
Codon, Nonsense [G05.365.590.195]
DNA Repeat Expansion [G05.365.590.220]
Frameshift Mutation [G05.365.590.265]
Gain of Function Mutation [G05.365.590.288]
Gene Amplification [G05.365.590.310]
Gene Duplication [G05.365.590.320]
Genomic Instability [G05.365.590.335]
Germ-Line Mutation [G05.365.590.350]
INDEL Mutation [G05.365.590.500]
Loss of Function Mutation [G05.365.590.538]
Mutagenesis, Insertional [G05.365.590.575]
Mutation Accumulation [G05.365.590.594]
Mutation Rate [G05.365.590.612]
Mutation, Missense [G05.365.590.650]
Point Mutation [G05.365.590.675]
Sequence Deletion [G05.365.590.762]
Sequence Inversion [G05.365.590.770]
Silent Mutation [G05.365.590.803]
Suppression, Genetic [G05.365.590.835]
Synthetic Lethal Mutations [G05.365.590.917]
Expand All
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Loss of Function Mutation
Preferred
Concept UI
M000623325
Scope Note
A mutation that causes a decrease in or elimination of a gene product's activity.
Terms
Loss of Function Mutation
Preferred Term
Term UI
T000911085
Date
11/01/2016
LexicalTag
NON
ThesaurusID
NLM (2018)
Null Mutation
Related
Concept UI
M000624519
Terms
Null Mutation
Preferred Term
Term UI
T000912627
Date
12/07/2016
LexicalTag
NON
ThesaurusID
NLM (2018)
Leaky Mutation
Narrower
Concept UI
M000624520
Terms
Leaky Mutation
Preferred Term
Term UI
T000912628
Date
12/07/2016
LexicalTag
NON
ThesaurusID
NLM (2018)
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