MeSH Browser

MeSH Heading: GTP Cyclohydrolase
Tree Number(s): D08.811.277.151.300
Unique ID: D006136
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006136
Scope Note: (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Entry Term(s): 7,8-Dihydroneopterintriphosphate Synthetase; GTP 8-Formylhydrolase; GTP Cyclohydrolase I; GTP Cyclohydrolase II; GTP Dihydrolase; GTP Ring-Opening Enzyme
CAS Type 1 Name: GTP 7,8-8,9-dihydrolase
Previous Indexing: Aminohydrolases (1974); Guanosine Triphosphate (1974)
Public MeSH Note: 91; was see under AMINOHYDROLASES 1975-90
History Note: 91(75); was see under AMINOHYDROLASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0009663
Scope Note: (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Terms: GTP Cyclohydrolase Preferred Term
Term UI T018611
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1975); 7,8-Dihydroneopterintriphosphate Synthetase
Term UI T018609
Date09/01/1983
LexicalTag NON
ThesaurusID UNK (19XX); GTP 8-Formylhydrolase
Term UI T018610
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); GTP Dihydrolase
Term UI T018612
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); GTP Ring-Opening Enzyme
Term UI T018613
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

GTP Cyclohydrolase MeSH Descriptor Data 2024