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GTP Cyclohydrolase MeSH Descriptor Data 2024

MeSH Heading
GTP Cyclohydrolase
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
(GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC (GTP cyclohydrolase I) and EC (GTP cyclohydrolase II).
Entry Term(s)
7,8-Dihydroneopterintriphosphate Synthetase
GTP 8-Formylhydrolase
GTP Cyclohydrolase I
GTP Cyclohydrolase II
GTP Dihydrolase
GTP Ring-Opening Enzyme
Registry Number
CAS Type 1 Name
GTP 7,8-8,9-dihydrolase
Previous Indexing
Aminohydrolases (1974)
Guanosine Triphosphate (1974)
Public MeSH Note
91; was see under AMINOHYDROLASES 1975-90
History Note
91(75); was see under AMINOHYDROLASES 1975-90
Date Established
Date of Entry
Revision Date
GTP Cyclohydrolase Preferred
GTP Cyclohydrolase II Narrower
GTP Cyclohydrolase I Narrower
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