MeSH Browser

MeSH Heading: Inositol 1,4,5-Trisphosphate
Tree Number(s): D02.033.800.519.400.350; D09.853.519.400.350; D09.894.480.350
Unique ID: D015544
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015544
Scope Note: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Entry Term(s): 1,4,5-IP3; 1,4,5-InsP3; Inositol 1,4,5-Triphosphate; Myo-Inositol 1,4,5-Trisphosphate; Myoinositol 1,4,5-Triphosphate
Registry Numbers: 85166-31-0
CAS Type 1 Name: D-myo-Inositol, 1,4,5-tris(dihydrogen phosphate)
Previous Indexing: Inositol Phosphates (1978-1989); Sugar Phosphates (1974-1977)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/07/05
Revision Date: 2004/07/07

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0023913
Registry Numbers: 85166-31-0
Scope Note: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.
Terms: Inositol 1,4,5-Trisphosphate Preferred Term
Term UI T046076
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); 1,4,5-IP3
Term UI T046075
Date12/27/1988
LexicalTag NON
ThesaurusID NLM (1990); Myo-Inositol 1,4,5-Trisphosphate
Term UI T046077
Date12/27/1988
LexicalTag NON
ThesaurusID NLM (1990); Myoinositol 1,4,5-Triphosphate
Term UI T046078
Date04/04/1989
LexicalTag NON
ThesaurusID NLM (1990); 1,4,5-InsP3
Term UI T046079
Date12/27/1988
LexicalTag NON
ThesaurusID NLM (1990); Inositol 1,4,5-Triphosphate
Term UI T046080
Date01/30/1989
LexicalTag NON
ThesaurusID NLM (1990)

Inositol 1,4,5-Trisphosphate MeSH Descriptor Data 2025