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Ivermectin MeSH Descriptor Data 2022


MeSH Heading
Ivermectin
Tree Number(s)
D02.540.576.500.997
Unique ID
D007559
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D007559
Scope Note
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Entry Term(s)
Eqvalan
Ivomec
MK-933
Mectizan
Stromectol
Pharm Action
Antiparasitic Agents
Insecticides
Registry Number
70288-86-7
CAS Type 1 Name
Ivermectin
Previous Indexing
Anthelmintics (1966-1986)
Antinematodal Agents (1974-1986)
Antiprotozoal Agents (1966-1986)
Filaricides (1973-1986)
Insecticides (1966-1986)
Lactones (1966-1986)
Public MeSH Note
1987; for MECTIZAN see IVERMECTIN 1987-1999
History Note
1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
Date Established
1987/01/01
Date of Entry
1986/06/16
Revision Date
2016/07/01
Ivermectin Preferred
Stromectol Narrower
Mectizan Narrower
MK-933 Narrower
Eqvalan Narrower
Ivomec Narrower
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