MeSH Browser

MeSH Heading: Keratins
Tree Number(s): D05.750.078.593.450; D12.776.220.475.450; D12.776.860.607
Unique ID: D007633
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007633
Scope Note: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Entry Term(s): Cytokeratin; Keratin; Keratin Associated Protein; Keratin-Associated Proteins; alpha-Keratin
Registry Numbers: 68238-35-7; 0
Related Numbers: 9008-18-8
See Also: Intermediate Filaments; Keratinocytes
Public MeSH Note: 2007; see KERATIN 1966-2006; KERATIN-ASSOCIATED PROTEINS was indexed under KERATIN 2000-2006, & under PROTEINS 1993-1999
History Note: 2007(1966)
Date Established: 2007/01/01
Date of Entry: 1999/01/01
Revision Date: 2022/04/07

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0011957
Registry Numbers: 68238-35-7
Related Numbers: 9008-18-8
Scope Note: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
Terms: Keratins Preferred Term
Term UI T665143
Date01/26/2006
LexicalTag NON
ThesaurusID NLM (2007); Cytokeratin
Term UI T022922
Date04/06/1984
LexicalTag NON
ThesaurusID UNK (19XX); Keratin
Term UI T022937
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966)

Keratins MeSH Descriptor Data 2025