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Neurofilament Proteins MeSH Descriptor Data 2022


MeSH Heading
Neurofilament Proteins
Tree Number(s)
D05.750.078.593.630
D12.776.220.475.630
D12.776.631.630
Unique ID
D016900
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016900
Annotation
/biosyn /‌physiol permitted
Scope Note
Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)
Entry Term(s)
Heavy Neurofilament Protein
Neurofilament Protein
Neurofilament Triplet Proteins
Registry Number
0
Previous Indexing
Intermediate Filament Proteins (1982-1991)
Nerve Tissue Proteins (1970-1982)
Public MeSH Note
92; NEUROFILAMENT PROTEINS was indexed under INTERMEDIATE FILAMENT PROTEINS 1982-91 & NERVE TISSUE PROTEINS 1977-82
Online Note
use NEUROFILAMENT PROTEINS (NM) to search NEUROFILAMENT PROTEINS 1977-91
History Note
92; was NEUROFILAMENT PROTEINS (NM) 1977-91
Date Established
1992/01/01
Date of Entry
1991/05/30
Revision Date
2020/06/17
Neurofilament Proteins Preferred
Neurofilament Triplet Proteins Narrower
Heavy Neurofilament Protein Narrower
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