MeSH Browser

MeSH Heading: Dysbindin
Tree Number(s): D12.776.210.500.410.250; D12.776.220.362.125; D12.776.543.268.250; D12.776.543.990.447; D12.776.631.262
Unique ID: D000074765
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074765
Scope Note: A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.
Entry Term(s): DTNBP1 Protein; Dysbindin-1; Dystrobrevin Binding Protein 1; Hermansky-Pudlak Syndrome 7 Protein
Previous Indexing: Dystrophin-Associated Proteins (2001-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000627424
Scope Note: A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.
Terms: Dysbindin Preferred Term
Term UI T000916989
Date03/09/2017
LexicalTag NON
ThesaurusID NLM (2018); Dystrobrevin Binding Protein 1
Term UI T000916991
Date03/09/2017
LexicalTag NON
ThesaurusID NLM (2018); DTNBP1 Protein
Term UI T000916990
Date03/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); Dysbindin-1
Term UI T000916992
Date03/09/2017
LexicalTag NON
ThesaurusID NLM (2018); Hermansky-Pudlak Syndrome 7 Protein
Term UI T000916994
Date03/09/2017
LexicalTag NON
ThesaurusID NLM (2018)

Dysbindin MeSH Descriptor Data 2024