- Concept UI
- M000762631
- Registry Numbers
- 0
- Scope Note
- Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.
- Terms
-
Neuroligins
Preferred Term
Term UI
T001132664
Date02/07/2023
LexicalTag
NON
ThesaurusID
NLM (2024)
-
Neuroligin
Term UI
T001136282
Date04/14/2023
LexicalTag
NON
ThesaurusID
NLM (2024)