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Neuroligins MeSH Descriptor Data 2024


MeSH Heading
Neuroligins
Tree Number(s)
D09.400.430.890.200.250.520.894
D12.776.395.550.200.250.520.894
D12.776.543.550.200.250.520.894
D12.776.631.641
D23.050.301.350.250.520.894
Unique ID
D000096785
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000096785
Scope Note
Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.
Entry Term(s)
Neuroligin
Registry Number
0
Previous Indexing
Nerve Tissue Proteins (1992-2023)
Public MeSH Note
2024
History Note
2024
Date Established
2024/01/01
Date of Entry
2023/07/26
Revision Date
2023/06/01
Neuroligins Preferred
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