- Concept UI
- M0122500
- Registry Number
- 0
- Scope Note
- A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
- Terms
-
Neural Cell Adhesion Molecule L1
Preferred Term
Term UI
T152505
LexicalTag
NON
ThesaurusID
NLM (2003)
-
NILE Glycoprotein
Term UI
T143115
LexicalTag
NON
ThesaurusID
NLM (2003)
-
Nerve Growth Factor-Inducible Large External Glycoprotein
Term UI
T143116
LexicalTag
NON
ThesaurusID
NLM (2003)
-
CALL Protein
Term UI
T152479
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
CamL1 Gene Product
Term UI
T152480
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
F11 Glycoprotein
Term UI
T152481
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
L1CAM
Term UI
T152490
LexicalTag
ACR
ThesaurusID
NLM (2003)
-
NILE Protein
Term UI
T152492
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
Cell Adhesion Molecule L1
Term UI
T152496
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
Cell Surface Glycoprotein L1
Term UI
T152497
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
Neural Adhesion Molecule L1
Term UI
T152504
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
NGF-Inducible Glycoprotein
Term UI
T143114
LexicalTag
NON
ThesaurusID
NLM (2003)
-
L1 Cell Adhesion Molecule
Term UI
T152485
LexicalTag
ACX
ThesaurusID
NLM (2003)