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Soluble Guanylyl Cyclase MeSH Descriptor Data 2025
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Entry Term(s)
Nitric Oxide Receptor
Nitric Oxide Receptors
Nitric Oxide-Sensitive Guanylyl Cyclase
Receptor, Nitric Oxide
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase, alpha Subunit
Soluble Guanylyl Cyclase, beta Subunit
Registry Numbers
EC 4.6.1.2
0
Related Numbers
EC 4.6.1.2
Public MeSH Note
2017; SOLUBLE GUANYLYL CYCLASE was indexed under GUANYLATE CYCLASE and RECEPTORS, CYTOPLASMIC AND NUCLEAR 2001-2016
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.