MeSH Browser

MeSH Heading: Soluble Guanylyl Cyclase
Tree Number(s): D08.811.520.650.600.750; D12.776.476.350.500
Unique ID: D000071756
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071756
Scope Note: A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Entry Term(s): Nitric Oxide Receptor; Nitric Oxide Receptors; Nitric Oxide-Sensitive Guanylyl Cyclase; Receptor, Nitric Oxide; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase, alpha Subunit; Soluble Guanylyl Cyclase, beta Subunit
Registry Numbers: EC 4.6.1.2; 0
Related Numbers: EC 4.6.1.2
Public MeSH Note: 2017; SOLUBLE GUANYLYL CYCLASE was indexed under GUANYLATE CYCLASE and RECEPTORS, CYTOPLASMIC AND NUCLEAR 2001-2016
History Note: 2017 (2016)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0400048
Registry Numbers: EC 4.6.1.2
Related Numbers: EC 4.6.1.2
Scope Note: A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Terms: Soluble Guanylyl Cyclase Preferred Term
Term UI T000896647
Date03/07/2016
LexicalTag NON
ThesaurusID NLM (2017); Nitric Oxide Receptor
Term UI T000896653
Date03/07/2016
LexicalTag NON
ThesaurusID NLM (2017); Nitric Oxide Receptors
Term UI T000896654
Date03/07/2016
LexicalTag NON
ThesaurusID NLM (2017); Nitric Oxide-Sensitive Guanylyl Cyclase
Term UI T000896655
Date03/07/2016
LexicalTag NON
ThesaurusID NLM (2017); Receptor, Nitric Oxide
Term UI T000896699
Date03/07/2016
LexicalTag NON
ThesaurusID NLM (2017); Soluble Guanylate Cyclase
Term UI T000901808
Date05/26/2016
LexicalTag NON
ThesaurusID NLM (2017)

Soluble Guanylyl Cyclase MeSH Descriptor Data 2025