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Soluble Guanylyl Cyclase MeSH Descriptor Data 2022


MeSH Heading
Soluble Guanylyl Cyclase
Tree Number(s)
D08.811.520.650.600.750
D12.776.476.350.500
Unique ID
D000071756
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071756
Scope Note
A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Entry Term(s)
Nitric Oxide Receptor
Nitric Oxide Receptors
Nitric Oxide-Sensitive Guanylyl Cyclase
Receptor, Nitric Oxide
Soluble Guanylate Cyclase
Soluble Guanylyl Cyclase, alpha Subunit
Soluble Guanylyl Cyclase, beta Subunit
Registry Number
EC 4.6.1.2
Related Numbers
EC 4.6.1.2
Public MeSH Note
2017; SOLUBLE GUANYLYL CYCLASE was indexed under GUANYLATE CYCLASE and RECEPTORS, CYTOPLASMIC AND NUCLEAR 2001-2016
History Note
2017 (2016)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/21
Soluble Guanylyl Cyclase Preferred
Soluble Guanylyl Cyclase, alpha Subunit Narrower
Soluble Guanylyl Cyclase, beta Subunit Narrower
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