MeSH Browser

MeSH Heading: alpha-Crystallins
Tree Number(s): D12.776.306.366.100; D12.776.580.157
Unique ID: D038201
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038201
Scope Note: A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Entry Term(s): Crystallins, alpha; alpha-Crystallin
Previous Indexing: Crystallins (1965-2002)
Public MeSH Note: 2003; for ALPHA-CRYSTALLIN see CRYSTALLINS 1982-2002
History Note: 2003; for ALPHA-CRYSTALLIN use CRYSTALLINS 1982-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0005389
Scope Note: A subclass of crystallins that provides the majority of refractive power and translucency to the lens (LENS, CRYSTALLINE) in VERTEBRATES. Alpha-crystallins also act as molecular chaperones that bind to denatured proteins, keep them in solution and thereby maintain the translucency of the lens. The proteins exist as large oligomers that are formed from ALPHA-CRYSTALLIN A CHAIN and ALPHA-CRYSTALLIN B CHAIN subunits.
Terms: alpha-Crystallins Preferred Term
Term UI T483160
Date02/22/2002
LexicalTag NON
ThesaurusID NLM (2003); alpha-Crystallin
Term UI T010051
Date03/18/1981
LexicalTag NON
ThesaurusID UNK (19XX); Crystallins, alpha
Term UI T483669
Date02/27/2002
LexicalTag NON
ThesaurusID NLM (2003)

alpha-Crystallins MeSH Descriptor Data 2024