MeSH Browser

MeSH Heading: Immunotoxins
Tree Number(s): D12.776.124.790.651.114.580.450; D12.776.377.715.548.114.580.450; D27.505.696.477.266.500; D27.888.569.279
Unique ID: D000922
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000922
Annotation: coordinate IM with specific toxin (IM) + specific immune substance (NIM)
Scope Note: Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.
Entry Term(s): Affinotoxin; Affinotoxins; Antibody-Toxin Conjugate; Antibody-Toxin Conjugates; Antibody-Toxin Hybrid; Antibody-Toxin Hybrids; Chimeric Toxin; Chimeric Toxins; Cytotoxin-Antibody Conjugate; Cytotoxin-Antibody Conjugates; Immunotoxin; Monoclonal Antibody-Toxin Conjugate; Monoclonal Antibody-Toxin Conjugates; Targeted Toxin; Targeted Toxins; Toxin Carrier; Toxin Carriers; Toxin Conjugate; Toxin Conjugates; Toxin-Antibody Conjugate; Toxin-Antibody Conjugates; Toxin-Antibody Hybrid; Toxin-Antibody Hybrids; Toxins, Chimeric; Toxins, Targeted
Pharm Action: Immunologic Factors
NLM Classification #: QW 630.5.I3
Previous Indexing: Antibodies, Monoclonal (1982-1986); Antigens, Surface (1979-1986); Antitoxins (1966-1986); Cytotoxicity, Immunologic (1978-1986); Ricin (1978-1985)
Public MeSH Note: 90; was ANTIBODY-TOXIN CONJUGATES 1987-89
Online Note: use IMMUNOTOXINS to search ANTIBODY-TOXIN CONJUGATES 1987-89
History Note: 90; was ANTIBODY-TOXIN CONJUGATES 1987-89
Date Established: 1987/01/01
Date of Entry: 1986/03/25
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Blood Proteins [D12.776.124]
    - Serum Globulins [D12.776.124.790]
      - Immunoglobulins [D12.776.124.790.651]
        
        Antibodies [D12.776.124.790.651.114]
        
        Immunoconjugates [D12.776.124.790.651.114.580]
        
        Abatacept [D12.776.124.790.651.114.580.225]
        
        Immunotoxins [D12.776.124.790.651.114.580.450]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Globulins [D12.776.377]
    - Serum Globulins [D12.776.377.715]
      - Immunoglobulins [D12.776.377.715.548]
        
        Antibodies [D12.776.377.715.548.114]
        
        Immunoconjugates [D12.776.377.715.548.114.580]
        
        Abatacept [D12.776.377.715.548.114.580.225]
        
        Immunotoxins [D12.776.377.715.548.114.580.450]

Chemical Actions and Uses [D27]
- Pharmacologic Actions [D27.505]
  - Physiological Effects of Drugs [D27.505.696]
    - Immunologic Factors [D27.505.696.477]
      - Immunoconjugates [D27.505.696.477.266]
        
        Immunotoxins [D27.505.696.477.266.500]

Chemical Actions and Uses [D27]
- Toxic Actions [D27.888]
  - Noxae [D27.888.569]

Immunotoxins Preferred

Concept UI: M0001373
Scope Note: Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.
Terms: Immunotoxins Preferred Term
Term UI T002728
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987); Antibody-Toxin Hybrid
Term UI T000998479
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Affinotoxin
Term UI T000998477
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Antibody-Toxin Conjugate
Term UI T000998478
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Cytotoxin-Antibody Conjugate
Term UI T000998480
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Monoclonal Antibody-Toxin Conjugate
Term UI T000998481
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Toxin-Antibody Hybrid
Term UI T000998482
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Toxin-Antibody Conjugate
Term UI T000998483
Date11/20/2019
LexicalTag NON
ThesaurusID NLM (2021); Affinotoxins
Term UI T002721
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Antibody-Toxin Conjugates
Term UI T002722
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Toxin-Antibody Conjugates
Term UI T002723
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Antibody-Toxin Hybrids
Term UI T002724
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Toxin-Antibody Hybrids
Term UI T002725
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Cytotoxin-Antibody Conjugates
Term UI T002726
Date11/25/1988
LexicalTag NON
ThesaurusID NLM (1988); Monoclonal Antibody-Toxin Conjugates
Term UI T002729
Date03/25/1986
LexicalTag NON
ThesaurusID UNK (19XX); Immunotoxin
Term UI T002727
Date01/05/1989
LexicalTag NON
ThesaurusID NLM (1990)

Toxins, Chimeric Broader

Concept UI: M0001374
Terms: Toxins, Chimeric Preferred Term
Term UI T002732
Date05/11/1990
LexicalTag NON
ThesaurusID NLM (1991); Chimeric Toxins
Term UI T002731
Date04/20/1990
LexicalTag NON
ThesaurusID NLM (1991); Chimeric Toxin
Term UI T002730
Date04/20/1990
LexicalTag NON
ThesaurusID NLM (1991); Toxin Carriers
Term UI T002734
Date01/05/1989
LexicalTag NON
ThesaurusID NLM (1990); Toxin Conjugate
Term UI T002735
Date01/05/1989
LexicalTag NON
ThesaurusID NLM (1990); Toxin Conjugates
Term UI T002736
Date01/05/1989
LexicalTag NON
ThesaurusID NLM (1990); Toxin Carrier
Term UI T002733
Date01/05/1989
LexicalTag NON
ThesaurusID NLM (1990)

Targeted Toxins Broader

Immunotoxins MeSH Descriptor Data 2024