MeSH Browser

MeSH Heading: Abatacept
Tree Number(s): D12.776.124.790.651.114.580.225; D12.776.377.715.548.114.580.225
Unique ID: D000069594
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000069594
Scope Note: A fusion protein immunoconjugate of the extracellular domain of CTLA4 and the Fc domain of human IgG1. It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. It is used in the treatment of RHEUMATOID ARTHRITIS.
Entry Term(s): BMS 188667; BMS-188667; BMS-224818; BMS224818; Belatacept; CTLA-4-Ig; CTLA4-Fc; CTLA4-Ig; CTLA4-Ig Immunoconjugate; Cytotoxic T Lymphocyte-Associated Antigen 4-Immunoglobulin; LEA29Y; Nulojix; Orencia
Pharm Action: Immune Checkpoint Inhibitors
Immunosuppressive Agents
Antirheumatic Agents
Registry Number: 7D0YB67S97
Related Numbers: 332348-12-6
See Also: CTLA-4 Antigen
Public MeSH Note: 2016; ABATACEPT was indexed under IMMUNOCONJUGATES 2002-2015
History Note: 2016 (2002)
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2020/02/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0498620
Registry Number: 0
Terms: CTLA-4-Ig Preferred Term
Term UI T675375
Date06/07/2006
LexicalTag ABB
ThesaurusID NLM (2006); Cytotoxic T Lymphocyte-Associated Antigen 4-Immunoglobulin
Term UI T000919361
Date03/20/2017
LexicalTag NON
ThesaurusID NLM (2006); CTLA4-Ig
Term UI T675377
Date06/07/2006
LexicalTag ABB
ThesaurusID NLM (2006); CTLA4-Ig Immunoconjugate
Term UI T000880726
Date05/28/2015
LexicalTag ABX
ThesaurusID NLM (2006); CTLA4-Fc
Term UI T675376
Date06/07/2006
LexicalTag ABB
ThesaurusID NLM (2006)

Abatacept MeSH Descriptor Data 2024