MeSH Browser

MeSH Heading: Pregnane X Receptor
Tree Number(s): D12.776.826.750.075; D12.776.930.778.175
Unique ID: D000077297
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077297
Scope Note: Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Entry Term(s): NR1I2; Nuclear Receptor Subfamily 1, Group I, Member 2; SXR Receptor; Steroid X Receptor; Steroid and Xenobiotic Receptor
Registry Numbers: 0
Public MeSH Note: 2019; PREGNANE X RECEPTOR was indexed under RECEPTORS, STEROID 2007-2018; and under RECEPTORS, CYTOPLASMIC AND NUCLEAR 1998-2006
History Note: 2019 (1998)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/28

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0287170
Registry Numbers: 0
Scope Note: Steroid receptor that binds and is activated by variety of endogenous compounds and XENOBIOTICS. It binds the response element in promoters of genes that encode CYTOCHROME P450 3A4 and ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 proteins, and also activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs, and endogenous compounds. It is activated by the antibiotic RIFAMPICIN and various plant metabolites, such as hyperforin, guggulipid, colupulone, and ISOFLAVONES.
Terms: Pregnane X Receptor Preferred Term
Term UI T000938869
Date01/09/2018
LexicalTag NON
ThesaurusID NLM (1998); Steroid and Xenobiotic Receptor
Term UI T000940016
Date02/02/2018
LexicalTag NON
ThesaurusID NLM (2019); NR1I2
Term UI T000940017
Date02/02/2018
LexicalTag ABB
ThesaurusID NLM (2019); SXR Receptor
Term UI T000938870
Date01/09/2018
LexicalTag ABX
ThesaurusID NLM (1998); Nuclear Receptor Subfamily 1, Group I, Member 2
Term UI T000938871
Date01/09/2018
LexicalTag NON
ThesaurusID NLM (2006); Steroid X Receptor
Term UI T000938872
Date01/09/2018
LexicalTag NON
ThesaurusID NLM (2000)

Pregnane X Receptor MeSH Descriptor Data 2025