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A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.
Entry Term(s)
CYP3A
CYP3A4
CYP3A5
Cytochrome P-450 CYP3A4
Cytochrome P-450 CYP3A5
Cytochrome P-450IIIA
Cytochrome P450 3A
Cytochrome P450 3A4
Cytochrome P450 3A5
Erythromycin N-Demethylase
Taurochenodeoxycholate 6-alpha-Monooxygenase
Registry Numbers
EC 1.14.14.1
EC 1.14.13.97
EC 1.14.14.1
Related Numbers
EC 1.14.13.97
EC 1.14.14.1
Public MeSH Note
2006; CYTOCHROME P-450 CYP3A was indexed under ARYL HYDROCARBON HYDROXYLASES & OXIDOREDUCTASES, N-DEMETHYLATING 1980-2005
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN.