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AlkB Homolog 4, Lysine Demethylase MeSH Descriptor Data 2022


MeSH Heading
AlkB Homolog 4, Lysine Demethylase
Tree Number(s)
D08.811.682.662.582.138
D08.811.682.690.416.139.937
Unique ID
D000071501
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071501
Scope Note
A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.
Entry Term(s)
Alkylated DNA Repair Protein AlkB Homolog 4
Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
Registry Number
EC 1.14.11.27
Previous Indexing
Dioxygenases (2014-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/06
Revision Date
2016/07/01
AlkB Homolog 4, Lysine Demethylase Preferred
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