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AlkB Enzymes MeSH Descriptor Data 2023


MeSH Heading
AlkB Enzymes
Tree Number(s)
D08.811.074.062
D08.811.682.690.416.139
Unique ID
D000071496
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071496
Scope Note
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
Entry Term(s)
AlkB Homologs
Alkylated DNA Repair Protein AlkB Homologs
Alkylation Repair Homolog Proteins
Alkylation Repair Homologs
Registry Number
EC 1.14.11.33
Previous Indexing
DNA Repair Enzymes (2004-2016)
Dioxygenases (2004-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/06
Revision Date
2016/06/28
AlkB Enzymes Preferred
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