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Homogentisate 1,2-Dioxygenase MeSH Descriptor Data 2022


MeSH Heading
Homogentisate 1,2-Dioxygenase
Tree Number(s)
D08.811.682.690.416.326
Unique ID
D050560
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050560
Scope Note
A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Entry Term(s)
Homogentisate Dioxygenase
Homogentisate Oxidase
Homogentisate Oxygenase
Homogentisic Acid Oxidase
Registry Number
EC 1.13.11.5
Related Numbers
9029-49-6
Previous Indexing
Dioxygenases (1969-2005)
See Also
Alkaptonuria
Public MeSH Note
2006; HOMOGENTISATE 1,2-DIOXYGENASE was indexed under DIOXYGENASES 1969-2005, OXYGENASES 1983-2004, & under HOMOGENTISIC ACID 1973-1982
History Note
2006(1969)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2012/07/03
Homogentisate 1,2-Dioxygenase Preferred
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