MeSH Browser

MeSH Heading: Tryptophan Oxygenase
Tree Number(s): D08.811.682.690.416.722
Unique ID: D014366
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D014366
Scope Note: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
Entry Term(s): TDO Dioxygenase; Tryptophan 2,3-Dioxygenase; Tryptophan Pyrrolase
Registry Number: EC 1.13.11.11
CAS Type 1 Name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
See Also: Tryptophan Hydroxylase
Public MeSH Note: 68
History Note: 68(65)
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0022091
Registry Number: EC 1.13.11.11
Scope Note: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.
Terms: Tryptophan Oxygenase Preferred Term
Term UI T042038
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1965); Tryptophan 2,3-Dioxygenase
Term UI T042037
Date11/20/1980
LexicalTag NON
ThesaurusID UNK (19XX); TDO Dioxygenase
Term UI T618552
Date11/19/2004
LexicalTag ABX
ThesaurusID NLM (2006); Tryptophan Pyrrolase
Term UI T042039
Date03/30/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Tryptophan Oxygenase MeSH Descriptor Data 2024