MeSH Browser

MeSH Heading: DNA Ligases
Tree Number(s): D08.811.074.500; D08.811.464.754.600
Unique ID: D011088
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011088
Annotation: do not confuse entry term POLYDEOXYRIBONUCLEOTIDE SYNTHETASES with entry term POLYRIBONUCLEOTIDE SYNTHETASE
Scope Note: Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).
Entry Term(s): DNA Joinases; DNA Ligase; Polydeoxyribonucleotide Ligases; Polydeoxyribonucleotide Synthetases; T4 DNA Ligase
Previous Indexing: Polynucleotide Synthetases (1974-1977)
Public MeSH Note: 98; see POLYDEOXYRIBONUCLEOTIDE SYNTHETASES 1991-97, see POLYNUCLEOTIDE SYNTHETASES 1978-90; for DNA LIGASES see POLYNUCLEOTIDE SYNTHETASES 1974-77, & see DNA LIGASE 1973-76
History Note: 98(77); for DNA LIGASES use POLYNUCLEOTIDE SYNTHETASES 1973-76
Date Established: 1991/01/01
Date of Entry: 1977/05/23
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0017169
Scope Note: Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).
Terms: DNA Ligases Preferred Term
Term UI T032604
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1978); DNA Ligase
Term UI T001006459
Date01/29/2020
LexicalTag NON
ThesaurusID NLM (2021); DNA Joinases
Term UI T032603
Date05/23/1977
LexicalTag NON
ThesaurusID UNK (19XX); Polydeoxyribonucleotide Ligases
Term UI T032606
Date05/23/1977
LexicalTag NON
ThesaurusID UNK (19XX); Polydeoxyribonucleotide Synthetases
Term UI T032607
Date11/06/1996
LexicalTag NON
ThesaurusID NLM (1998)

DNA Ligases MeSH Descriptor Data 2024