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DNA-(Apurinic or Apyrimidinic Site) Lyase MeSH Descriptor Data 2022


MeSH Heading
DNA-(Apurinic or Apyrimidinic Site) Lyase
Tree Number(s)
D08.811.074.750
D08.811.520.241.225
Unique ID
D043603
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D043603
Scope Note
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Entry Term(s)
AP Endonuclease
AP Lyase
Apurine-Apyrimidine Endonuclease
Apurinic DNA Endonuclease
Apurinic Endonuclease
DNA Lyase (Apurinic or Apyrimidinic)
Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Registry Number
EC 4.2.99.18
Previous Indexing
Carbon-Oxygen Lyases (1978-2003)
Public MeSH Note
2004; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE was indexed under CARBON-OXYGEN LYASES 1996-2003, DEOXYRIBONUCLEASES 1978-1982, ENDODEOXYRIBONUCLEASES 1983-1995, ENDONUCLEASES 1978-1982 & LYASES 1978-1980
History Note
2004; use DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE (NM) 1980-2003
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2013/07/09
DNA-(Apurinic or Apyrimidinic Site) Lyase Preferred
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