MeSH Browser

MeSH Heading: DNA-(Apurinic or Apyrimidinic Site) Lyase
Tree Number(s): D08.811.074.750; D08.811.520.241.225
Unique ID: D043603
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D043603
Scope Note: A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Entry Term(s): AP Endonuclease; AP Lyase; Apurine-Apyrimidine Endonuclease; Apurinic DNA Endonuclease; Apurinic Endonuclease; DNA Lyase (Apurinic or Apyrimidinic); Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Registry Number: EC 4.2.99.18
Previous Indexing: Carbon-Oxygen Lyases (1978-2003)
Public MeSH Note: 2004; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE was indexed under CARBON-OXYGEN LYASES 1996-2003, DEOXYRIBONUCLEASES 1978-1982, ENDODEOXYRIBONUCLEASES 1983-1995, ENDONUCLEASES 1978-1982 & LYASES 1978-1980
History Note: 2004; use DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE (NM) 1980-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0073416
Registry Number: EC 4.2.99.18
Scope Note: A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Terms: DNA-(Apurinic or Apyrimidinic Site) Lyase Preferred Term
Term UI T103419
LexicalTag ABX
ThesaurusID NLM (2004); AP Endonuclease
Term UI T103400
LexicalTag ABX
ThesaurusID NLM (2004); Endodeoxyribonuclease (Apurinic or Apyrimidinic)
Term UI T103413
LexicalTag NON
ThesaurusID NLM (2004); Apurine-Apyrimidine Endonuclease
Term UI T103409
LexicalTag NON
ThesaurusID NLM (2004); Apurinic DNA Endonuclease
Term UI T103410
LexicalTag ABX
ThesaurusID NLM (2004); Apurinic Endonuclease
Term UI T103411
LexicalTag ABX
ThesaurusID NLM (2004); DNA Lyase (Apurinic or Apyrimidinic)
Term UI T544320
Date06/25/2003
LexicalTag NON
ThesaurusID NLM (2004); AP Lyase
Term UI T103401
LexicalTag ABX
ThesaurusID NLM (2004)

DNA-(Apurinic or Apyrimidinic Site) Lyase MeSH Descriptor Data 2024