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DNA Ligase ATP MeSH Descriptor Data 2022


MeSH Heading
DNA Ligase ATP
Tree Number(s)
D08.811.074.500.500
D08.811.464.754.600.500
Unique ID
D000072481
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072481
Scope Note
ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.
Entry Term(s)
ATP-Dependent DNA Ligase
DNA Ligase I
DNA Ligase II
DNA Ligase III
DNA Ligase IIIalpha
DNA Ligase IV
DNA Ligases, ATP-Dependent
LIGIIIalpha Protein
Polydeoxyribonucleotide Synthase ATP
Registry Number
EC 6.5.1.1
Related Numbers
EC 6.5.1.1
Public MeSH Note
2018; DNA LIGASE (ATP) was indexed under DNA LIGASES 1986-2016; DNA LIGASE IIIALPHA was indexed under DNA LIGASES 1991-2017
History Note
2018 (1986)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/06/30
DNA Ligase ATP Preferred
DNA Ligase I Narrower
DNA Ligase IIIalpha Narrower
DNA Ligase IV Narrower
DNA Ligase III Narrower
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