MeSH Browser

MeSH Heading: DNA Ligase ATP
Tree Number(s): D08.811.074.500.500; D08.811.464.754.600.500
Unique ID: D000072481
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072481
Scope Note: ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.
Entry Term(s): ATP-Dependent DNA Ligase; DNA Ligase I; DNA Ligase II; DNA Ligase III; DNA Ligase IIIalpha; DNA Ligase IV; DNA Ligases, ATP-Dependent; LIGIIIalpha Protein; Polydeoxyribonucleotide Synthase ATP
Related Numbers: EC 6.5.1.1
Public MeSH Note: 2018; DNA LIGASE (ATP) was indexed under DNA LIGASES 1986-2016; DNA LIGASE IIIALPHA was indexed under DNA LIGASES 1991-2017
History Note: 2018 (1986)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000619283
Related Numbers: EC 6.5.1.1
Scope Note: ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.
Terms: DNA Ligase ATP Preferred Term
Term UI T000903465
Date06/30/2016
LexicalTag NON
ThesaurusID NLM (2017); DNA Ligases, ATP-Dependent
Term UI T000902766
Date06/13/2016
LexicalTag NON
ThesaurusID NLM (2017); Polydeoxyribonucleotide Synthase ATP
Term UI T000903467
Date06/30/2016
LexicalTag NON
ThesaurusID NLM (2017); ATP-Dependent DNA Ligase
Term UI T001085933
Date08/03/2020
LexicalTag NON
ThesaurusID NLM (2022)

DNA Ligase ATP MeSH Descriptor Data 2024