MeSH Browser

MeSH Heading: Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Tree Number(s): D08.811.074.062.968; D08.811.682.662.582.242; D08.811.682.690.416.139.992
Unique ID: D000071516
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071516
Scope Note: A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Entry Term(s): AlkB Homolog 9 Protein; Alpha-Ketoglutarate-Dependent Dioxygenase; Fat Mass and Obesity Associated (FTO) Protein; Fat Mass and Obesity Associated Protein
Previous Indexing: Mixed Function Oxygenases (2007-2016); Oxo-Acid-Lyases (2007-2016); Proteins (2008-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000614982
Scope Note: A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Terms: Alpha-Ketoglutarate-Dependent Dioxygenase FTO Preferred Term
Term UI T000895768
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017); Alpha-Ketoglutarate-Dependent Dioxygenase
Term UI T000895780
Date02/23/2016
LexicalTag NON
ThesaurusID NLM (2017); Fat Mass and Obesity Associated (FTO) Protein
Term UI T000898936
Date04/14/2016
LexicalTag NON
ThesaurusID NLM (2017); Fat Mass and Obesity Associated Protein
Term UI T000895767
Date02/23/2016
LexicalTag NON
ThesaurusID NLM (2017); AlkB Homolog 9 Protein
Term UI T000895769
Date02/23/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Alpha-Ketoglutarate-Dependent Dioxygenase FTO MeSH Descriptor Data 2024