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Alpha-Ketoglutarate-Dependent Dioxygenase FTO MeSH Descriptor Data 2023


MeSH Heading
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Tree Number(s)
D08.811.074.062.968
D08.811.682.662.582.242
D08.811.682.690.416.139.992
Unique ID
D000071516
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071516
Scope Note
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Entry Term(s)
AlkB Homolog 9 Protein
Alpha-Ketoglutarate-Dependent Dioxygenase
Fat Mass and Obesity Associated (FTO) Protein
Fat Mass and Obesity Associated Protein
Registry Number
EC 1.14.11.33
Previous Indexing
Mixed Function Oxygenases (2007-2016)
Oxo-Acid-Lyases (2007-2016)
Proteins (2008-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/06/28
Alpha-Ketoglutarate-Dependent Dioxygenase FTO Preferred
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