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Cytochrome P-450 Enzyme System MeSH Descriptor Data 2022


MeSH Heading
Cytochrome P-450 Enzyme System
Tree Number(s)
D08.244.453
D08.811.682.690.708.170
D12.776.422.220.453
Unique ID
D003577
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003577
Annotation
general or unspecified; prefer specific cytochrome P-450's
Scope Note
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Entry Term(s)
CYP450 Family
CYP450 Superfamily
Cytochrome P-450
Cytochrome P-450 Enzyme
Cytochrome P-450 Enzymes
Cytochrome P-450 Families
Cytochrome P-450 Monooxygenase
Cytochrome P-450 Oxygenase
Cytochrome P-450 Superfamily
Cytochrome P-450-Dependent Monooxygenase
Cytochrome P450
Cytochrome P450 Superfamily
Cytochrome p450 Families
P-450 Enzyme
P-450 Enzymes
P450 Enzyme
P450 Enzymes
Registry Number
9035-51-2
CAS Type 1 Name
Cytochrome P 450
Previous Indexing
Cytochromes (1966-1972)
Public MeSH Note
73; CYTOCHROME P-450 OXYGENASE was indexed under CYTOCHROME P-450 & OXYGENASES 1977-96
History Note
73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
Entry Combination
antagonists & inhibitors:Cytochrome P-450 Enzyme Inhibitors
Date Established
1973/01/01
Date of Entry
1999/01/01
Revision Date
2020/05/27
Cytochrome P-450 Enzyme System Preferred
Cytochrome P-450 Oxygenase Narrower
Cytochrome P-450 Monooxygenase Narrower
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