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A cytochrome P450 enzyme involved in oxidizing POLYUNSATURATED FATTY ACIDS (PUFA) to PUFA epoxides which function as potent lipid mediators. This enzyme, encoded by CYP2J2 gene, metabolizes ARACHIDONIC ACID to epoxyeicosatrienoic acids (EETs) which produce biological effects including VASODILATION.
Entry Term(s)
Arachidonate Epoxygenase
Arachidonic Acid Epoxygenase
CYP2J2
Cytochrome P-450 Arachidonate Oxygenase
Cytochrome P-450 Epoxygenase
NADPH-Dependent Arachidonic Acid Epoxygenase
Registry Numbers
EC 1.14.14.1
0
Public MeSH Note
2022; ARACHIDONATE EPOXYGENASE was indexed under CYTOCHROME P-450 ENZYME SYSTEM 1987-2021, and under OXYGENASES 1985-2008
A cytochrome P450 enzyme involved in oxidizing POLYUNSATURATED FATTY ACIDS (PUFA) to PUFA epoxides which function as potent lipid mediators. This enzyme, encoded by CYP2J2 gene, metabolizes ARACHIDONIC ACID to epoxyeicosatrienoic acids (EETs) which produce biological effects including VASODILATION.