MeSH Browser

MeSH Supplementary: trichostatin A
Unique ID: C012589
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/C012589
Entry Term(s): 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; A 300; TSA antibioitc
Pharm Action: Antifungal Agents
Protein Synthesis Inhibitors
Histone Deacetylase Inhibitors
Related Numbers: 58880-19-6
Previous Indexing: HYDROXAMIC ACIDS (76-94)
Heading Mapped to: *Hydroxamic Acids
Frequency: 3173
Note: chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES
Source: J Antibiot (Tokyo) 29(1):1;1976; J Antibiot (Tokyo) 31(10):939;1978
Date of Entry: 1976/01/01
Revision Date: 2020/08/19

trichostatin A MeSH Supplementary Concept Data 2024