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An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.
Entry Term(s)
ELAVL1 protein
HuR Antigen
HuR Paraneoplastic Encephalomyelitis Antigen
HuR Protein
Registry Numbers
0
Previous Indexing
ELAV Proteins (2005-2015)
RNA-Binding Proteins (2000-2015)
Public MeSH Note
2016; see HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS 2012-2015
An RRM protein that binds to the 3'-UTR region of mRNAs and increases their stability. In EMBRYONIC STEM CELLS, it binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs and preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), to stabilize them and promote differentiation.