MeSH Browser

MeSH Heading: Aldo-Keto Reductase Family 1 Member C2
Tree Number(s): D08.811.682.047.150.700.156.750; D08.811.682.047.820.284.875
Unique ID: D000074422
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074422
Scope Note: Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).
Entry Term(s): AKR1C2 Protein; Dihydrodiol Dehydrogenase 2; Dihydrodiol Dehydrogenase-Bile Acid Binding Protein
Previous Indexing: Hydroxysteroid Dehydrogenases (2001-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2018/07/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000626529
Scope Note: Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).
Terms: Aldo-Keto Reductase Family 1 Member C2 Preferred Term
Term UI T000915853
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2018); Dihydrodiol Dehydrogenase 2
Term UI T000915852
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2018); AKR1C2 Protein
Term UI T000915854
Date02/16/2017
LexicalTag ABX
ThesaurusID NLM (2018); Dihydrodiol Dehydrogenase-Bile Acid Binding Protein
Term UI T000915863
Date02/16/2017
LexicalTag NON
ThesaurusID NLM (2000)

Aldo-Keto Reductase Family 1 Member C2 MeSH Descriptor Data 2024