Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Aldo-Keto Reductase Family 1 Member C2 MeSH Descriptor Data 2025


MeSH Heading
Aldo-Keto Reductase Family 1 Member C2
Tree Number(s)
D08.811.682.047.150.700.156.750
D08.811.682.047.820.284.875
Unique ID
D000074422
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074422
Scope Note
Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).
Entry Term(s)
AKR1C2 Protein
Dihydrodiol Dehydrogenase 2
Dihydrodiol Dehydrogenase-Bile Acid Binding Protein
Registry Numbers
EC 1.1.1.357
Previous Indexing
Hydroxysteroid Dehydrogenases (2001-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2018/07/13
Aldo-Keto Reductase Family 1 Member C2 Preferred
page delivered in 0.141s