MeSH Browser

MeSH Heading: Amifampridine
Tree Number(s): D02.092.080.060.500; D03.383.725.050.060.500
Unique ID: D000077770
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077770
Scope Note: 4-Aminopyridine derivative that acts as a POTASSIUM CHANNEL blocker to increase release of ACETYLCHOLINE from nerve terminals. It is used in the treatment of CONGENITAL MYASTHENIC SYNDROMES.
Entry Term(s): 3,4-Diaminopyridine; Amifampridine Phosphate; Firdapse; Ruzurgi
Pharm Action: Neuromuscular Agents
Potassium Channel Blockers
Related Numbers: 54-96-6; 8HF8FIN815
CAS Type 1 Name: 3,4-Pyridinediamine
Public MeSH Note: 2019; see 3,4-DIAMINOPYRIDINE 1978-2018; AMIFAMPRIDINE was indexed under 4-AMINOPYRIDINE/analogs & derivatives 1990-2018; under AMINOPYRIDINES 1978-1989; and under PYRIDINES 1978-1979
History Note: 2019 (1978)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amifampridine MeSH Descriptor Data 2024