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Chaperone-Mediated Autophagy MeSH Descriptor Data 2022


MeSH Heading
Chaperone-Mediated Autophagy
Tree Number(s)
G04.011.625
Unique ID
D000080642
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000080642
Scope Note
A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY.
Previous Indexing
Autophagy (2000-2019)
Public MeSH Note
2020
History Note
2020
Date Established
2020/01/01
Date of Entry
2019/07/09
Revision Date
2019/07/08
Chaperone-Mediated Autophagy Preferred
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