MeSH Browser

MeSH Heading: WAP Four-Disulfide Core Domain Protein 2
Tree Number(s): D12.776.298.500
Unique ID: D000081102
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000081102
Scope Note: A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.
Entry Term(s): Epididymal Secretory Protein E4; WFDC2 Protein
Registry Numbers: 0
Public MeSH Note: 2020
History Note: 2020
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/08/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

Concept UI: M000649709
Registry Numbers: 0
Scope Note: A secreted 25-kDa glycoprotein member of the Whey-acidic-protein (WAP) four-disulfide core (WFDC) domain family with tissue specific expression in the EPIDIDYMIS. It is also expressed in a limited number of other organs which include female reproductive tract, breast tissue, kidney, regions of the respiratory tract and nasopharynx. The protein is a biomarker for epithelial ovarian cancer.
Terms: WAP Four-Disulfide Core Domain Protein 2 Preferred Term
Term UI T000959851
Date06/06/2019
LexicalTag NON
ThesaurusID NLM (2020); Epididymal Secretory Protein E4
Term UI T000959852
Date06/06/2019
LexicalTag NON
ThesaurusID NLM (2020); WFDC2 Protein
Term UI T000962956
Date07/02/2019
LexicalTag NON
ThesaurusID NLM (2020)

WAP Four-Disulfide Core Domain Protein 2 MeSH Descriptor Data 2025